Impact of nebulized unfractionated heparin and N-acetylcysteine in management of smoke inhalation injury
نویسندگان
چکیده
منابع مشابه
Does a Nebulized Heparin/N-acetylcysteine Protocol Improve Outcomes in Adult Smoke Inhalation?
BACKGROUND Smoke inhalation is a major source of morbidity and mortality. Heparin and N-acetylcysteine treatment has potential efficacy in inhalation injury. We investigated the impact of a heparin/N-acetylcysteine/albuterol nebulization protocol in adult patients with inhalation injury. METHODS A retrospective review was performed of adult inhalation injury patients, admitted to a regional b...
متن کاملA histological study on the effects of aqueous extract of Althea officinalis on epithelial and submucosal mucocilliary system of rat trachea following inhalation of cigarette smoke
The contents of cigarette smoke (gaseous and solid phases) have been attributed to a variety of diseases in the respiratory and cardiovascular systems and have been associated with development of different types of cancers. In respiratory system, these compounds specially cause epithelial cell injury, and interfere with mucocilliary transport (MTC). Various parts of Althea officinalis (family M...
متن کاملA histological study on the effects of aqueous extract of Althea officinalis on epithelial and submucosal mucocilliary system of rat trachea following inhalation of cigarette smoke
The contents of cigarette smoke (gaseous and solid phases) have been attributed to a variety of diseases in the respiratory and cardiovascular systems and have been associated with development of different types of cancers. In respiratory system, these compounds specially cause epithelial cell injury, and interfere with mucocilliary transport (MTC). Various parts of Althea officinalis (family M...
متن کاملNebulized anticoagulants for acute lung injury - a systematic review of preclinical and clinical investigations
BACKGROUND Data from interventional trials of systemic anticoagulation for sepsis inconsistently suggest beneficial effects in case of acute lung injury (ALI). Severe systemic bleeding due to anticoagulation may have offset the possible positive effects. Nebulization of anticoagulants may allow for improved local biological availability and as such may improve efficacy in the lungs and lower th...
متن کاملEffects of heparin and lisofylline on pulmonary function after smoke inhalation injury in an ovine model.
OBJECTIVE This study evaluates the effects of heparin alone and in combination with lisofylline, 1-(5-R-hydroxyhexyl)3,7-dimethylxanthine, on severe smoke injury. DESIGN Prospective animal study with concurrent controls. SETTING An animal laboratory. SUBJECTS Eighteen 1-yr-old female sheep, weighing 24-32 kg. INTERVENTIONS After smoke exposure and tracheostomy, animals were divided into...
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عنوان ژورنال:
دوره 13 شماره
صفحات -
تاریخ انتشار 2009